[shiego100]

I would go 1. Leonardo 2. Jonny Depp 3. Brad Pitt 4. Matt Damon. 5. Tom Cruise 

[joemama4241]

From what movies ive seen with them:

1. Depp
2. Cruise
3. Dicaprio
4. Damon
5. Pitt

[dizelpatches]

brrooooooooooooooooooooooooooooooooooooooooooooooo 12 3 4 5

[Ran King]

1. Depp
2. Damon
3. Dicaprio
4. Pitt
5. Cruise

[Tacocat69]

As much as well all love Depp, he still plays the same character type in most roles. Same goes for Cruise (that's why his performance in Tropic Thunder was so hilarious). So my order based on objective acting and screen presence is:

1. DiCaprio
2. Pitt
3. Damon
4. Depp
5. Cruise

[CodLordFish]

Based on my favorite to least favorite
1. Johnny Depp
2. Matt Damon
3. Leonardo DiCaprio
4. Brad Pitt
5. Tom Cruise