I think the advice would be different depending on your career path. I have an office job so no idea if this would be helpful, but the last job I managed to land I got through a consulting aganecy. Just give them your CV and they hand it to everyone and they're more likely to be read because companies already trust the consulting agency. You can get a good few interviews that way.
Other good advice I've heard from other industries is to hand-write your application/CV and send it through the mail, nobody expects that in this digital age so it makes you stand out. Anything you can do to stand out is good. As long as it's legal. Don't show up to an interview naked or with a gun or both.