Not without a massive paradigm shift. Every other company that has tried, failed. For that matter, Nintendo kinda failed as well with some of their other characters. I think the history that gave Mario the perfect slot to be such an iconic gaming mascot is pretty much impossible to repeat, and if something happens that he falls out of favor, there's probably just gonna be a bunch of smaller mascots, kind of like how Sonic, Kirby, and others are right now.